Reports on trials of children with cerebral palsy and the side effects

Clinical trials of botox have been performed on children with cerebral palsy in a pediatric hospital in the period 2010-2014. And it was found, through follow-up, that there were systemic side effects, defined as lower respiratory tract diseases, generalized weakness, dysphagia (swallowing) and death.

A total of 591 children were subjected to 2219 injections and systemic adverse events were reported in 77 injection episodes, corresponding to 3.6% of injections.

The study concluded that a history of dysphagia (swelling) and / or pneumonia are factors that increase the risk of systemic side effects after botulinum toxin.

A research article on muscle damage in children with cerebral palsy

The link below is a locked article (from 2015) that one must have access to. But there is a preface to the article that one can read freely: it is a trial of botulinum toxin in 10 children with cerebral palsy. The average age of the children was 11 years and 7 months.

The experiment was performed to determine the relationship between muscle damage and botulinum toxin. Treatment was first performed in the calf muscle and then muscle biopsies (tissue samples) were taken from the same muscle.

Results of the trial: neurogenic atrophy (nerve dysfunction) was found in the medial gastrocnemius (lay muscle) in 6 of participants between 4 months and 3 years after botulinum toxin treatments. Type 1 fiber loss with type 2 fiber loss was found related to the number of injections of botulinum toxin. The impact of these changes in muscle structure on muscle function in CP is not clear in the conclusion. However, it is important to consider different muscles or injection sites in the muscle or allow longer periods between injections.

Edward M. Goldstein’s Trial

A report published in 2006 and authored by physician Edward M. Goldstein. it deals with trials of botulinum toxin in children with cerebral palsy. The experiments went, among other things. to test how much toxin the children could tolerate without botulism. The report needs special access. It can also be purchased for $ 40.

A lawyer defending the children

A lawyer says he represents children with cerebral palsy who have received botulism following botox injections:

More trials for adults and children

A link to a summary of 863 clinical trials of botulinum toxin in humans. Some trials are underway – others are over. 134 experiments are on children.

Experiments in the 1980s with botulinum toxin. A list of various publications published: