Why some get sick and others don’t

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Thousands around the world get botox treatments effortlessly, and doctors and botox manufacturers say the toxin is safe. A botox treatment also tends to be problem-free.

Why some people get side effects and others no side effects, no one knows exactly. But here are some commandments:

The injection site is important

One important thing that the practitioner must adhere to is to inject the sites recommended by the manufacturer. Ie stick to areas where there are not so many blood vessels that can be affected. Obviously, the toxin can spread if the needle strikes a vein. One of the places at risk of injecting is in the temples and the side of the forehead as it is an area of ​​many veins. Therefore, the manufacturer recommends that the toxin be injected between the eyebrows at 5 points (blood supply is not that great in that area – glabella) as well as in the forehead wrinkles in the middle of the forehead. Permission is also given to inject the wrinkles at the eyes ( crows feet ). See the article here that has been granted treatment:


See an article here about the blood supply to the face. It deals with complications with fillers and gives an idea of ​​how important it is to hit right:


here are also theories that if the injection is given too close to the eye (possibly with a dilution that gives more spread) it can cause the toxin to spread to the muscles that control the eye, giving it that is called “sixth nerve palsy” (article on sixth nerve palsy here on the site).

Fat layer in the subcutaneous tissue

The thickness of the fat layer in the subcutaneous skin also has a bearing on how well the treatment can withstand, as the fat layer – like other tissues – can absorb the toxin and reduce the risk of spreading.

Men and women have a different fat layer and muscle thickness. The less fat / muscle, the less tissue to absorb the toxin and the greater the risk of spread.


Of course, the amount of toxin that is injected also has a big impact on the side effects. Manufacturers have given specific guidelines on how much toxin is max. must be injected at each site to minimize the risk of spread.

Underlying diseases are important for botox tolerance

The toxin should not be given to those who have an underlying muscle or nervous disease, such as myastenia gravis. This is stated on the leaflet.


All types of drugs can cause a hypersensitivity reaction. One can get ugly symptoms that can get worse over the years and set themselves up as autoimmune diseases. All because you have been given a substance that you could not tolerate. The following text (inserted as a picture) tells how two different drugs – botulinum toxin and the enzyme choline acetyltransferase (both of which affect the same neurotransmitter acetylcholine) – have produced almost the same kind of side effects and autoimmune reactions :

Botulinum toxin can cause botulism, which is of course fatal in itself, but botulinum toxin also disappears from the body again – typically within a few months and up to a year! Therefore, many symptoms become free again after approx. one year.

But if you stay ill for years after an injection, it is wrong to keep focusing on the toxin itself. – Because if the toxin itself is the only thing that makes people sick, everyone will become more or less sick by injection, as ALL injectable drugs circulate in the body. Therefore, even antitoxin is administered intramuscularly.

When we shout that we have become ill from botox, no one takes us seriously and no lawyers want to fight for the sick from it because we simply cannot explain why we have fallen ill while others do not even get symptoms after doses of up to 1000 units. BUT what really happens is that some people get horrible immune reactions which lead to a devastating health condition – this is written in the leaflet as RARE – HYPERSENSITIVITY (rare hypersensitivity reaction). But maybe it’s not that rare even! And if that happens, it will be more relevant to blame on the hypersensitivity reaction rather than botox.

As with other types of treatments, vaccines and drugs in general, there is just one that does not tolerate them: the immune system can react and start attacking the body’s own cells – and autoimmune diseases such as POTS, cardiovascular disease can occur. problems, nerve damage (small-fiber neuropathy), etc.

We have also started discussing the “mast cell reaction”. – Mast cells are connective tissue cells – they are part of the immune system. histamine in allergy.

Clinics should have a checklist

It would be good if the botox clinics had a checklist they reviewed with their clients before treatment.

It would also be good if clients were told where to find the side effect list. On the whole, it is a scandal that clients / customers do not get information about side effects from the manufacturer’s own package leaflet, which you do when buying medicines at the pharmacy. It should be a matter of course to get thorough and proper information on the side effects, so that one decides on a botox treatment on an informed basis – not just on trust .

And lastly, autoimmune reactions should be taken seriously if the symptoms do not disappear again.

You get no treatment if things go wrong

One last important thing to know is that there is no medical protocol to treat the side effects of botox or the spread of the poison . And since doctors have no action plan, they can’t help ! This is true in many countries.

In case of symptoms you can report the side effects, which is important to get done to update the side effects lists.